|
Crohn Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Nine SNPs located in TNFSF15 on chromosome 9 were related to CD in Han individuals from Southern China.
|
31844038 |
2019 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
PF-06480605 was generally well tolerated, and binding of soluble TL1A was maintained throughout the dose interval, supporting further study of PF-06480605 in patients with IBD and other inflammatory conditions.
|
31758576 |
2020 |
|
Pouchitis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
SNP genotyping was performed for 8 SNPs reportedly associated with UCAC and pouchitis, namely: ELF1 (rs7329174), FCGR2A, (rs1801274), interleukin-1β (IL-1B; rs1143627), ITLN1 (rs2274910), MHC (rs7765379), TNFα (rs1799964), TNFSF15 (rs3810936), and UHMK1 (rs768910), using TaqMan genotyping technologies.
|
31671425 |
2019 |
|
Atherosclerosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
<b>Background:</b> Tumour necrosis factor like cytokine 1A (TL1A), which is a member of tumour necrosis factor alpha superfamily (TNF-α), is a novel indicator of atherosclerosis.<b>Objective:</b> Smoking is an established stimulant of TNF-α.
|
31646918 |
2019 |
|
Coronary Artery Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Gensini score and Syntax score were positively correlated with TL1A levels (<i>r</i> = 0.420, <i>p</i> < 0.001, and <i>r</i> = 0.402, <i>p</i> < 0.001, respectively).<b>Conclusions:</b> Non-smoker CAD patients have higher TLA1 levels that are promising biomarker for diagnosing CAD and indicating CAD lesion complexity.
|
31646918 |
2019 |
|
Arteriosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
<b>Background:</b> Tumour necrosis factor like cytokine 1A (TL1A), which is a member of tumour necrosis factor alpha superfamily (TNF-α), is a novel indicator of atherosclerosis.<b>Objective:</b> Smoking is an established stimulant of TNF-α.
|
31646918 |
2019 |
|
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ten relevant genes were evaluated.SNPs rs4263839 and rs6478108 of TNFSF15 associated with an increased risk of IBS; IL6 rs1800795 increased the risk for Caucasian IBS patients which diagnosed by Rome III criteria; and IL23R rs11465804 increased the risk for IBS-C patients.
|
31615448 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
This study aimed to investigate the function of TNF-like ligand 1A (TL1A) in the tumorigenesis and progression of gastric cancer (GC).
|
31571922 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to investigate the function of TNF-like ligand 1A (TL1A) in the tumorigenesis and progression of gastric cancer (GC).
|
31571922 |
2019 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to investigate the function of TNF-like ligand 1A (TL1A) in the tumorigenesis and progression of gastric cancer (GC).
|
31571922 |
2019 |
|
Multiple Sclerosis
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
Moreover, TL1A expression was found to be associated with the clinical and MRI findings of MS patients suggesting its possible involvement in the establishment or preservation of immune system homeostasis or in the regulation of inflammatory activity.
|
31445379 |
2019 |
|
Mitral Valve Stenosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, TL1A expression was found to be associated with the clinical and MRI findings of MS patients suggesting its possible involvement in the establishment or preservation of immune system homeostasis or in the regulation of inflammatory activity.
|
31445379 |
2019 |
|
Multiple Sclerosis, Relapsing-Remitting
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed significant decrease in TL1A expression in RRMS compared to other study groups.
|
31445379 |
2019 |
|
Graft-vs-Host Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease.
|
31379829 |
2019 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease.
|
31358760 |
2019 |
|
Colitis
|
0.080 |
Biomarker
|
disease |
BEFREE |
Neutralization of TL1A by soluble DR3 ameliorates both DSS and anti-CD40 antibody-induced colitis.
|
31358760 |
2019 |
|
Osteopenia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Whether DR3 and TL1A contribute towards bone loss in menopause-induced primary osteoporosis however, remains unknown.
|
31299941 |
2019 |
|
Primary osteoporosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Whether DR3 and TL1A contribute towards bone loss in menopause-induced primary osteoporosis however, remains unknown.
|
31299941 |
2019 |
|
Anemia, Sickle Cell
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TNFSF/TNFRSF cytokine gene expression in sickle cell anemia: Up-regulated TNF-like cytokine 1A (TL1A) and its decoy receptor (DcR3) in peripheral blood mononuclear cells and plasma.
|
31255916 |
2019 |
|
Cardiac Arrest
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We investigated the expression TL1A/DR3/DcR3 cytokine signaling pathway in peripheral blood mononuclear cells (PBMC) and their corresponding plasma levels in SCA subjects who presented with acute painful episodes.
|
31255916 |
2019 |
|
Hemangioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Retroviral infection of bEnd.3 cells with TNFSF15 leads to inhibition of VEGF production and retardation of hemangioma formation.
|
31242765 |
2019 |
|
Hemangioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the meantime, TNF superfamily 15 (TNFSF15) (also known as vascular endothelial growth inhibitor), an antiangiogenic cytokine, is highly expressed in normal brain blood vessels but diminished in HB lesions.
|
31242765 |
2019 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, the molecular mechanisms of TL1A in UC development are poorly understood.
|
31176785 |
2019 |
|
Colitis
|
0.080 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate the role of TL1A in colitis, and reveal the regulatory mechanism of TL1A in chronic colitis development.
|
31176785 |
2019 |
|
Venous Thromboembolism
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
TNFSF15 up-regulation was confirmed at the protein level in ECFC supernatants, and the in vivo relevance of these findings was further corroborated by demonstrating that also the plasmatic levels of TNFSF15 are increased in uVTE patients.
|
31135876 |
2020 |